Sickle cell disease as a protective factor against Malaria
DOI:
https://doi.org/10.54283/RACSaude.v3i2.2023.p4-9Keywords:
Sickle cell disease, Malaria, ProtectionAbstract
Malaria is one of the main causes of morbidity and mortality in sub-Saharan Africa, where there is also a high prevalence of sickling. This high frequency of HbAS is believed to be a result of the innate resistance to malaria conferred on carriers of the HbS variant. The aim of this work is to describe the mechanisms conferred by sickling as a protective factor against malaria, for which a narrative literature review was carried out. Multiple studies corroborate the protective nature of HbAS against malaria and several hypotheses of molecular mechanisms as well as immune system reactions are pointed out. However, although multiple studies have been carried out on sickle cell disease as a protective factor against malaria, they are not conclusive.
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Gong L, Parikh S, Rosenthal PJ, Greenhouse B. Biochemical and immunological mechanisms by which sickle cell trait protects against malaria. Malar J. 2013;12(317):1–9.
Uyoga S, Macharia AW, Ndila CM, Nyutu G, Shebe M, Awuondo KO, et al. The indirect health effects of malaria estimated from health advantages of the sickle cell trait. Nat Commun [Internet]. 2019;10(1):1–7. doi:http://dx.doi.org/10.1038/s41467-019-08775-0
Santos GR, Queiroz LAB , Rodrigues JVS, Oliveira MVM. Deficiência de G6PD, Anemia Falciforme e suas implicações sobre a malária. Rev Bionorte. 2017;6:13–21.
Ambrose EE, Smart LR, Charles M, Hernandez AG, Latham T, Hokororo A, et al. Surveillance for sickle cell disease, United Republic of Tanzania. Bull World Health Organ. 2020;98(12):859–68. doi: https://doi.org/10.2471%2FBLT.20.253583
Duraisingh MT, Lodish HF. Sickle cell MicroRNAs inhibit the malaria parasite. Cell Host Microbe. 2012;12(2):127–8. doi: https://doi.org/10.1016/j.chom.2012.08.001
Monteiro MFAD. Efeitos de factores do hospedeiro e parasitários na susceptibilidade à malária e gravidade da doença - estudo de alguns polimorfismos eritrocitários e das espécies de Plasmodium [Internet]. Portugal: Instituto de Higiene e Medicina Tropical da Universidade Nova de Lisboa; 2011 [citado dezembro 2022]. Disponível em: http://www2.fcsh.unl.pt/giid-clunl/civ/civdocs/Rodrigues(2012)Metodologia_Naturalista_Interações_Verbais-GaudiumSciendi1-.pdf
Williams TN, Mwangi TW, Roberts DJ, Alexander ND, Weatherall DJ, Wambua S, et al. An immune basis for malaria protection by the sickle cell trait. PLoS Med. 2005;2(5):0441–5. doi: http://dx.doi.org/10.1371/journal.pmed.0020128
Williams TN, Obaro SK. Sickle cell disease and malaria morbidity: A tale with two tails. Trends Parasitol. 2011;27(7):315–20. doi: http://dx.doi.org/10.1016/j.pt.2011.02.004
Oliveira AMS. Análise da cinética de crescimento do Plasmodium falciparum em eritrócitos com alterações hematológicas [monografia]. [Brasil]: Universidade Federal do Rio Grande do Norte;2017.32p.
Eridani S. Sickle cell protection from malaria. Hematol Rep. 2011;3(3):72–7. doi: https://www.mdpi.com/2038-8330/3/3/e24
Sepúlveda N. Tudo sobre Malária, Genética, e Estatística, ou talvez não! Boletim da Sociedade Portuguesa de Estatística. 2015;41–8.
Piel FB, Patil AP, Howes RE, Nyangiri OA, Gething PW, Williams TN, et al. Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis. Nat Commun. 2010;1(104). doi: http://doi.org/10.1038/ncomms1104
Aidoo M, Terlouw DJ, Kolczak MS, McElroy PD, Ter Kuile FO, Kariuki S, et al. Protective effects of the sickle cell gene against malaria morbidity and mortality. Lancet. 2002;359(9314):1311–2. doi: https://doi.org/10.1016/s0140-6736(02)08273-9
Luzzatto L. Sickle cell anaemia and malaria. Mediterr J Hematol Infect Dis. 2012;4(1). doi: https://doi.org/10.4084/mjhid.2012.065
Archer NM, Petersen N, Clark MA, Buckee CO, Childs LM, Duraisingh MT. Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition. Proc Natl Acad Sci U S A. 2018;115(28):7350–5. doi: https://doi.org/10.1073/pnas. 1804388115
Oniyangi O, Omari AA. Malaria chemoprophylaxis in sickle cell disease. Cochrane database Syst Rev. 2019;2019(11):14. doi: https://doi.org/10.1002/14651858.CD003489.pub2
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